The territory of the present Municipality of Colfelice was crossed, in the Roman age, by the Via Latina (Latin Road), by the "Pedemontana" Road, connecting Arpinum and Aquinum, and by the Vitularia Road, which linked the two roads passing along the present Rio Proibito.

In 1976 some remains of a large Roman villa were found along the "Pedemontana", in a place called Ara Murata.

A productive settlement dating back to the Republican Age was found in 1997 in the area of Camponi (in a tableland overlooking the Rivulet Rio Sottile), during the excavations for the construction of the high speed railway line between Rome and Naples.

The archaeologists have judged particularly interesting some ponds covered with earthenware and the crescent-shaped inside hollow with a central circular depression.