The origin of the Municipality of Colfelice is rather recent: it dates back to 1923, when the Royal Decree n. 2703 of 6 December detached the two hamlets of Coldragone and Villafelice from the Municipality of Roccadarce and gave them a complete administrative autonomy. After few years Colfelice passed from the jurisdiction of the Province of Caserta (then called "Terra di Lavoro") to the new Province of Frosinone, established in 1927, and consequently from the Region of Campania to the Region of Latium.

The name of the new Municipality was made up of Col (from Coldragone) and felice (from Villafelice). Colfelice, or rather Coldragone, appears in the local history with unequivocal certainty only when Giacomo Boncompagni came into possession of the Dukedom of Arce, towards the end of the 16th century. The Duke started intense and fervent works of reconstruction of the Dukedoms with lasting building, trade and economic activities, such as the introduction of the wool industry in Isola del Liri (1581), the purchase of the paper mill of Carnello (1583) and the construction of the Palazzo Ducale in Isola del Liri. In 1583 he also started the construction of Colle Drago (Coldragone), a block of houses, on a small hill of his lands in the Dukedom of Arce. The name Colle Drago was due to the presence of a dragon in the Boncompagnis’ coat of arms.

About the origin of Coldragone there is a legend too. Once upon a time there was a dragon that spread terror among the unarmed and docile creatures living in a small hamlet built on the slopes of a hill…

The dragon lived in a dark cave on the sides of the hill, hardly accessible and therefore cause of fear and threat. It came out of the cave to attack and devour the grazing animals until one day a sow, to defend its piglet, killed it and freed the place from the monster.

Giacomo Boncompagni died in 1612 and his son Gregorio I inherited Coldragone together with the Dukedom of Arce. Later the Dukedom passed to Giacomo II (1629) and Ugo (1636). In this period the place suffered an earthquake (1654) and a pestilence (1656).

The Boncompagnis took a direct interest in Coldragone again in 1746, when the hamlet was rebuilt and permanently inhabited after it had been probably deserted for decades. The Duke Gaetano Boncompagni (1731 – 1777) built a church dedicated to Saint Joseph and Saint Gaetano.

The government of the Boncompagnis in the Dukedoms of Arce and Sora ended in the second half of the 18th century. The last Duke was Antonio II, who did not show any interest in his lands. So on 1st September 1796 the two Dukedoms went back to the King of Naples.